PMC:4572492 / 13546-14247 JSONTXT

{"project":"2_test","denotations":[{"id":"26140448-19875614-2053695","span":{"begin":165,"end":167},"obj":"19875614"},{"id":"26140448-19875614-2053696","span":{"begin":234,"end":236},"obj":"19875614"}],"text":"The T1D application used the Diabetes Control and Complications Trial (DCCT) sample in which 667 individuals were conventionally treated and 637 intensively treated.18 In this sample, an earlier GWAS of HbA1c levels in type 1 diabetes18 showed that rs1358030 near SORCS1 (10q25.1 [MIM: 606283]) interacts with treatment type (conventional versus intensive) on HbA1c levels (quarterly measured values spanning 6.5 years). To demonstrate that the JLS testing framework could leverage the interaction effect without knowledge of the interacting variable, we analyzed the association of rs1358030 with the average, inverse normal transformed HbA1c value, assuming the treatment variable was not available."}