Early onset cataracts and hearing loss have rarely been reported in genetic conditions, with the collagenopathies, Alport (MIM 104200), Stickler (MIM 108300) and Marshall (MIM 154780) syndromes being the most common. This work identified MAF mutations as principal cause for a disorder combining cataracts and hearing loss in a multisystem developmental syndrome independently recognized by Gripp et al.1 and Aymé and Philip.2 Though the clinical presentation of subjects within this study resembles that described in the context of FLS, we note that this overlap is only partial. Moreover, FLS has been applied to clinically variable phenotypes of likely heterogeneous etiology (here exemplified by cases 10, 11, and 12). We therefore propose the eponym Aymé-Gripp syndrome for the disorder caused by mutations affecting residues of the GSK3 phosphorylation motifs in order to distinguish the phenotype described here from that reported by Fine and Lubinsky.3