PMC:4570283 / 30362-31023 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4570283","sourcedb":"PMC","sourceid":"4570283","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4570283","text":"(B) The Kalash are fixed for the ancestral allele of the MCM6 intronic variant (rs4988235) that is associated with lactose intolerance. The derived allele that is associated with lactase persistence is present at moderate frequency in populations from Pakistan (left panel and upper dashed line in the right panel). Forward-time simulations (right panel) suggest that recent isolation and genetic drift cannot explain the observed pattern for this functional polymorphism in the Kalash population. Only 1/1,000 replicates (represented by orange lines) reach fixation after 500 generations of drift (∼12,500 years ago if we assume a generation time of 25 years).","tracks":[]}