PMC:4570283 / 16880-17537 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4570283","sourcedb":"PMC","sourceid":"4570283","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4570283","text":"Two variants that were highly differentiated between the Kalash and the neighboring Pakistani populations stood out. One variant, rs4988235 (c.−13910C\u003eT), which influences lactase (LCT [MIM: 603202]) expression and confers lactose tolerance, is fixed for the ancestral lactose-intolerant allele in the Kalash. The derived allele, however, is reported to be present at a moderate frequency (average 29%) in Pakistan.32 Forward-time simulations demonstrated that the observed pattern cannot easily be explained by recent genetic drift, given that only 0.1% of the 1,000 simulations achieved fixation for the ancestral allele after 500 generations (Figure 4A).","tracks":[{"project":"2_test","denotations":[{"id":"25937445-17701907-2051096","span":{"begin":415,"end":417},"obj":"17701907"}],"attributes":[{"subj":"25937445-17701907-2051096","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#ec93ac","default":true}]}]}}