PMC:4570283 / 12739-13615 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4570283","sourcedb":"PMC","sourceid":"4570283","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4570283","text":"PSMC analysis applied to the high-coverage Kalash, three African genomes (YRI, LWK, and MKK), and six non-African genomes showed that the Kalash, like other non-Africans, experienced a severe bottleneck 50,000–70,000 years ago. The Kalash recovered slightly after the bottleneck but never achieved an effective population size above 20,000, as observed in the GIH (the other South Asian genome) and other non-African genomes, except the MXL (Figure 2A). The Kalash have maintained a low effective size below 10,000 for more than 20,000 years before the present. This pattern of unusually small effective population size in the Kalash is also supported by the estimate from the decay of LD, which was significantly lower (p = \u003c 2 × 10−14) than that of neighboring populations from Pakistan (Figure 2B), although the estimated absolute sizes differed between the two approaches.","tracks":[]}