The dashed lines on the two top left plots in Figure S1 show the fitted curves used to adjust the genotype counts, N(p2(1 − p) + f(p)) and N(p(1 − p)2 − f(p)) for p∈[0, 0.5], for the number of minor alleles inherited from the father and mother, respectively. These two curves are fitted simultaneously, and if the estimates given by SHAPEIT2 are accurate, then these should be close to the expected curves, with the fitted parameters β being close to zero. In the example in Figure S1 this is not true (although the tails of the dashed lines can be ignored given that there is no data in these regions). The dashed lines on the two lower plots on the left show Nf(p) and −Nf(p), respectively, and show how the estimated cell counts will be adjusted.