Here, we have demonstrated the improved functionality implemented in the latest version of our software package, PREMIM and EMIM, which has been updated to incorporate haplotype estimation in SHAPEIT2 when modeling parent-of-origin effects. Naturally, computation time is increased as a result of using SHAPEIT2, but the analysis still remains quite feasible for any realistically sized study. Although the focus of this current investigation is on detection of parent-of-origin effects, we note that PREMIM and EMIM offer wider functionality, such as the ability to test for maternal-genotype effects or mother-child genotype interactions, with or without the inclusion of parent-of-origin effects. The software can also be used to increase the power when analyzing an unrelated case-control dataset by incorporating case or control parental data when available.