PMC:4564992 / 41533-42406 JSONTXT

{"project":"2_test","denotations":[{"id":"26320892-23297363-2052550","span":{"begin":54,"end":56},"obj":"23297363"}],"text":"We also re-analyzed the data of Cordell et al. (2013),35 testing for a paternally inherited imprinting effect on chromosome 12 and a maternally inherited imprinting effect on chromosome 13. Without using estimated parent of origin, the analysis on chromosome 12 gave a minimum p value of 2.10 × 10−8 at rs11065987; using estimated parent of origin gave a p value of 4.16 × 10−7 at the same SNP. On chromosome 13, the most significant SNP, rs7982677, gave p values of 9.54 × 10−7 and 6.97 × 10−6 when not estimating and estimating parent of origin, respectively. Plots of these analyses, with and without using estimated parent of origin, are shown in Figures S5 and S6. Again we see a general decrease in the significance of the most significant results when using haplotype estimation, weakening the evidence that these genomic regions genuinely harbor imprinting effects."}