PMC:4564992 / 2735-3830 JSONTXT

{"project":"2_test","denotations":[{"id":"26320892-24439386-2052488","span":{"begin":151,"end":152},"obj":"24439386"},{"id":"26320892-21933173-2052489","span":{"begin":263,"end":264},"obj":"21933173"},{"id":"26320892-19966805-2052490","span":{"begin":311,"end":312},"obj":"19966805"},{"id":"26320892-20016592-2052491","span":{"begin":348,"end":349},"obj":"20016592"},{"id":"26320892-20016592-2052492","span":{"begin":388,"end":389},"obj":"20016592"},{"id":"26320892-24571439-2052493","span":{"begin":518,"end":519},"obj":"24571439"},{"id":"26320892-25757221-2052494","span":{"begin":627,"end":628},"obj":"25757221"},{"id":"26320892-18523590-2052495","span":{"begin":992,"end":993},"obj":"18523590"}],"text":"Parent-of-origin effects due to genomic imprinting (or due to interactions with imprinted loci) have been observed for multiple traits in outbred mice.2 In humans, parent-of-origin effects have been observed at known imprinted regions for a variety of phenotypes,3 including chromosome 14q32 in type 1 diabetes,4 chromosome 7q32 in type 2 diabetes,5 and chromosome 11p15 in breast cancer.5 Parent-of-origin effects have also been observed on chromosomes 5p13 and 14q12 in relation to specific language impairment (SLI)6 and at the filaggrin gene (FLG [MIM: 135940]) on chromosome 1q21 in relation to childhood atopic dermatitis7 (although this FLG effect was interpreted as being most likely due to a direct effect of maternal genotype, rather than to differing effects of the alleles inherited from the different parents). Experimental studies investigating potential parent-of-origin effects detected at COL2A1 (MIM: 120140) and ABCA4 (MIM: 601691) in children with congenital toxoplaxmosis8 showed isoform-specific epigenetic modifications consistent with imprinting in both COL2A1 and ABCA4."}