PMC:4564992 / 1691-2734 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4564992","sourcedb":"PMC","sourceid":"4564992","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4564992","text":"Parent-of-origin effects relate to the situation where traits are influenced by the allele inherited from only one parent (e.g., the mother), with the allele from the other parent (e.g., the father) having little or no effect. More generally, parent-of-origin effects can be defined as effects where the alleles inherited from the different parents have differing effects on some phenotype of interest. This phenomenon is not the same as a direct effect of maternal genotype. A maternal-genotype effect occurs when an offspring’s phenotype is altered (perhaps in utero) by the maternal genotype, regardless of the allele actually transmitted to the child. One biological mechanism that can lead to parent-of-origin effects is genomic imprinting, the phenomenon whereby either the maternally or the paternally inherited allele is expressed, while the other allele is silenced. The mechanisms underlying imprinting are not yet fully understood, but are believed to involve epigenetic processes including histone acetylation and DNA methylation.1","tracks":[{"project":"2_test","denotations":[{"id":"26320892-23917626-2052487","span":{"begin":1042,"end":1043},"obj":"23917626"}],"attributes":[{"subj":"26320892-23917626-2052487","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#93c1ec","default":true}]}]}}