PMC:4564992 / 14697-15494 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4564992","sourcedb":"PMC","sourceid":"4564992","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4564992","text":"Separation of cell 9 into two cells, 9a and 9b, leads to a situation in which the multinomial likelihood uses counts from 16 (rather than the originally considered 15) cells. However, we might want to analyze datasets in which only a proportion of the case-parent trios have been phased. This could occur, for example, if some of the case-parent trios have been genotyped only at a candidate SNP (so there are no surrounding SNPs to provide phase information), whereas other trios have been more densely genotyped. Thus, we actually need to consider the counts from 17 cells, with cells 9, 9a, and 9b all considered as separate categories. In Appendix A, we derive the multinomial likelihood that includes data for cells 9, 9a, and 9b in terms of the genotype relative-risk parameters of interest.","tracks":[]}