PMC:4564992 / 14013-14696 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4564992","sourcedb":"PMC","sourceid":"4564992","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4564992","text":"In our updated version of EMIM, we use the software package SHAPEIT231,32 to estimate haplotypes in the trio and then use this information to infer the parental origin of the “2” allele in the child. We thus consider cells 9a and 9b separately, resulting in a likelihood contribution of μ4R1S1Ipγ11 if a trio is deemed to fall into category 9a or μ4R1S1Imγ11 if a trio is deemed to fall into category 9b. (Trios where there is still some ambiguity regarding parental origin could, in theory, contribute fractional counts to both cells; however, as noted later, we did not find any advantage in allowing for this as compared to just using the most likely parent-of-origin assignment).","tracks":[{"project":"2_test","denotations":[{"id":"26320892-22138821-2052531","span":{"begin":71,"end":73},"obj":"22138821"},{"id":"26320892-23269371-2052531","span":{"begin":71,"end":73},"obj":"23269371"}],"attributes":[{"subj":"26320892-22138821-2052531","pred":"source","obj":"2_test"},{"subj":"26320892-23269371-2052531","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#ece493","default":true}]}]}}