PMC:4564992 / 13208-14012 JSONTXT

{"project":"2_test","denotations":[{"id":"26320892-21181895-2052530","span":{"begin":593,"end":595},"obj":"21181895"}],"text":"In previous versions of EMIM (≤ 2.07), the multinomial likelihood contribution from such a trio wasP(gm=12,gf=12,gc=12 or 21|dis=1)=μ4R1S1(Ip+Im)γ11where dis = 1 denotes the event that the child is diseased, gc denotes the ordered (maternal and paternal) alleles in the child, μ4 denotes a nuisance (mating-type stratification) parameter, and γ11 denotes an optional mother-child genotype-interaction parameter that can be estimated if desired. This likelihood contribution comes from combining into a single cell (cell 9) the contributions from cells 9a and 9b of Table 2 of Ainsworth et al.,20 in which cell 9a corresponds to the (unobservable) situation that the “2” allele in the child came from the father and 9b to the (unobservable) situation that the “2” allele in the child came from the mother."}