The URLs for data presented herein are as follows:1000 Genomes, http://browser.1000genomes.org
dbSNP, http://www.ncbi.nlm.nih.gov/projects/SNP/
ExAC Browser, http://exac.broadinstitute.org/
NHLBI Exome Sequencing Project (ESP) Exome Variant Server, http://evs.gs.washington.edu/EVS/
OMIM, http://www.omim.org/
RefSeq, http://www.ncbi.nlm.nih.gov/RefSeq