2.1. Targets Mining of Main Active Components of QSYQ
The main active components of QSYQ were used to study the mechanism of QSYQ. By literature retrieval from PubMed and CNKI database, the main active components of QSYQ were obtained based on the principles that components are the main efficacy components, have rich content, and can be absorbed into the blood. The information of the main active components of QSYQ is shown in Table 1.
The targets' information of main active components of QSYQ was obtained from two parts: pharmacophore virtual screening and the component-protein interaction database including ChEMBL (https://www.ebi.ac.uk/chembl/#) [11] and STITCH 3.1 (http://stitch.embl.de/) [12]. The 27 pharmacophore models which were applied to virtual screen were constructed by our laboratory team [13, 14]. ChEMBL is a manually curated chemical database which contains compound bioactivity data against drug targets. STITCH is a database in which every interaction has a confidence score, and the interactions with a confidence score > 0.7 were selected.