AMDA levels
ADMA levels were significantly increased in the hypothalamus and medulla of GTN treated rats, when compared to CT group. Conversely, we did not detect any significant differences in mesencephalon (Fig. 3). No significant difference was observed in serum ADMA concentrations between GTN and CT groups (Fig. 4).
Fig. 3 Cerebral levels of ADMA in rats injected with glyceryl trinitrate (GTN) or vehicle (CT). ADMA levels were evaluated after 4 h of GTN or vehicle injection. Data are expressed as mean ± SD, Mann Whitney test, *p <0.05 vs vehicle (CT)
Fig. 4 Serum levels of ADMA in rats injected with glyceryl trinitrate (GTN) or vehicle (CT). ADMA levels in serum were evaluated after 4 h of GTN or vehicle injection. Data are expressed as mean ± SD