In contrast, eosinophil recruitment within genetically susceptible mice had detrimental effects for the host. Increased eosinophil recruitment resulted in enhanced IL-5 and led to decreased fungal clearance and damage of lung epithelial cells (Huffnagle et al., 1998). Further to this, surfactant protein D, as described above, promotes the recruitment of eosinophils, through enhancement of IL-5 production (Holmer et al., 2014).