Among 20 isolates, seven suppressors were picked for further study after we removed weak suppressors, sterile mutants, and escapers (animals that produced nonviable progeny at nonpermissive temperatures) (Table 1). We confirmed their rescue by measuring survival at 25° (Figure 6A). Because the screens were performed with F2 progeny from mixed F1s, it is possible that some suppressors share the same mother and contain mutations on the same alleles; yet, several suppressors have distinct phenotypes. For example, S4, one of the strong suppressors (Figure 6A), does not show a Dpy phenotype but shows Eat (pale body color) and Unc (uncoordinated movement). Interestingly, several suppressors of mua-3(uy19) from two independent screens are smaller (Sma) or shorter (Dpy) in body length compared to wild-type. Because one of the major pathways that determines body size in C. elegans is a TGFβ pathway, our results suggest the intriguing possibility that MUA-3 may be involved in TGFβ regulation in C. elegans as in Marfan syndrome pathology in humans.