Study subjects
The test cohort included 663 patients who had been diagnosed with either clinical stage IIIA or IV NSCLC and had received first-line platinum-based chemotherapy (no prior surgery, radiotherapy, or concurrent chemoradiotherapy) between March 2005 and January 2010. The association of the WEE1 tag SNP with the efficacy of chemotheraputic regimens was reviewed and evaluated. The validation cohort included 264 NSCLC patients who accepted the platinum-gemicitabine regimen in Shanghai Pulmonary Hospital between June 2010 and May 2013. All the patients had histologically confirmed NSCLC with the presence of at least one measurable and evaluable lesion. Eastern Cooperative Oncology Group performance status (ECOG PS) for the patients is 0–2 and the cardiovascular, hepatic, hematologic, and renal functions of the patients have been reviewed to assess chemotherapy tolerance.