PMC:4457944 / 5036-6602
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4457944","sourcedb":"PMC","sourceid":"4457944","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4457944","text":"Using ADMIXTURE17 and principal-component analysis (PCA)18 (Figure 1A), we estimated the average proportion of non-African ancestry in the Egyptians to be 80% and dated the midpoint of the admixture event by using ALDER20 to around 750 years ago (Table S2), consistent with the Islamic expansion and dates reported previously.13,14 The Ethiopian populations showed, as expected, a more variable spectrum of genetic introgression (Figure 1B). Consistent with previous reports,13 the Amhara and Oromo were shown to have around 50% of their genome derived from non-Africans, the introgressed proportion in the Somali and Wolayta amounted to 40%–30%, and the Gumuz showed negligible amounts of non-African admixture. The date of the midpoint of these admixture events was 2,500–3,000 years ago (Table S2), although one notable exception was the Oromo, who have shown evidence of multiple admixture events.21 These conclusions are consistent with previous reports13,21 and fit with linguistic records.22 Furthermore, the distribution of maternal (mtDNA) and paternal (Ychr) lineages revealed sex-biased admixture patterns in Ethiopians (Figure S2), such that there was less male-mediated than female-mediated Middle Eastern backflow. The affinity of the Egyptian African component with the modern East and West African populations (green component in Figure 1B, K = 5) could be due to either a continuity of human presence in the area or recent gene flow from neighboring African regions resulting from demographic processes and slave trade over the last two millennia.23","tracks":[{"project":"2_test","denotations":[{"id":"26027499-19648217-2049880","span":{"begin":15,"end":17},"obj":"19648217"},{"id":"26027499-16862161-2049881","span":{"begin":56,"end":58},"obj":"16862161"},{"id":"26027499-23410830-2049882","span":{"begin":219,"end":221},"obj":"23410830"},{"id":"26027499-22726845-2049883","span":{"begin":329,"end":331},"obj":"22726845"},{"id":"26027499-22253600-2049883","span":{"begin":329,"end":331},"obj":"22253600"},{"id":"26027499-22726845-2049884","span":{"begin":475,"end":477},"obj":"22726845"},{"id":"26027499-24550290-2049885","span":{"begin":901,"end":903},"obj":"24550290"},{"id":"26027499-22726845-2049886","span":{"begin":961,"end":963},"obj":"22726845"},{"id":"26027499-24550290-2049886","span":{"begin":961,"end":963},"obj":"24550290"},{"id":"26027499-19403539-2049887","span":{"begin":996,"end":998},"obj":"19403539"},{"id":"26027499-9291916-2049888","span":{"begin":1564,"end":1566},"obj":"9291916"}],"attributes":[{"subj":"26027499-19648217-2049880","pred":"source","obj":"2_test"},{"subj":"26027499-16862161-2049881","pred":"source","obj":"2_test"},{"subj":"26027499-23410830-2049882","pred":"source","obj":"2_test"},{"subj":"26027499-22726845-2049883","pred":"source","obj":"2_test"},{"subj":"26027499-22253600-2049883","pred":"source","obj":"2_test"},{"subj":"26027499-22726845-2049884","pred":"source","obj":"2_test"},{"subj":"26027499-24550290-2049885","pred":"source","obj":"2_test"},{"subj":"26027499-22726845-2049886","pred":"source","obj":"2_test"},{"subj":"26027499-24550290-2049886","pred":"source","obj":"2_test"},{"subj":"26027499-19403539-2049887","pred":"source","obj":"2_test"},{"subj":"26027499-9291916-2049888","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#ecec93","default":true}]}]}}