I'd like to thank Paolo Peretto for critical readings and comments to the manuscript and Luis Puelles and Aldo Fasolo for useful discussions on the initial version of this theory. I would also like to thank Aldo Fasolo and Maria Fosca Franzoni for the golgi slides of Lacerta Sicula. This work is dedicated to the memory of Prof. Aldo Fasolo and Prof. Maria Fosca Franzoni. This work was supported by Progetti di Ricerca di Interesse Nazionale (PRIN)-Peretto 2010-2011; and by Luzzati-Ricerca Locale 2013.