Healthy weight participants
The most common finding across studies of healthy weight participants was that motivational state (i.e., fasted or satiated state) affected brain activation to food. Fasting often increased responses to high-calorie foods in areas associated with processing of reward and stimuli salience [OFC (66, 69, 71, 72), striatum (65, 69, 72), insula (69, 71)], decision making [OFC (66, 69, 71, 72), striatum (65, 69, 72)], implicit learning [OFC (66, 69, 71, 72), putamen (66, 71)], and the processing of visual cues [fusiform gyrus (68, 71, 74)]. Gender differences were identified in responses to food cues with females displaying greater activation in a variety of brain regions implicated in attention, emotion, recollective memory, and decision making (67, 68, 74).