DNA preparation, and exome sequencing
DNA was prepared from venous blood or saliva samples using standard procedures. Exome capture was performed using the 2.1M NimbleGen Exome reagent (Roche NimbleGen, Madison, WI), and 75 base paired end sequencing on the Illumina (San Diego, CA) platform was performed as previously described (Lemaire et al., 2013). Coverage statistics are provided in Supplementary file 1B.