(B) A schematic representation of the domain structure of proteins (ZNF750, AJUBA, FAT1, NFE2L2, PTCH1, SUFU, CREBBP, and BAP1) encoded by SMGs shows the location of somatic variants identified in ESCC tumors. DNA mutations and amino acid changes are shown. The C-terminal nuclear localization sequence (NLS) of ZNF750 is shown in black.