Web Resources The URLs for data presented herein are as follows:Agilent SureSelect Solution, http://www.genomics.agilent.com/en/home.jsp Database for Annotation, Visualization, and Integrated Discovery (DAVID), http://david.abcc.ncifcrf.gov/ Kyoto Encyclopedia of Genes and Genomes (KEGG), http://www.genome.jp/kegg MutSigCV, http://www.broadinstitute.org/cancer/cga/mutsig OMIM, http://omim.org/ PolyPhen-2, http://genetics.bwh.harvard.edu/pph2/ Sequence Read Archive (SRA), http://www.ncbi.nlm.nih.gov/sra SIFT, http://sift.jcvi.org/ UCSC Genome Browser, http://genome.ucsc.edu/