Table 1  Regions of Homozygosity and Exome Sequencing
Chr   Start   End   Length (Mb)   CCDS Genes   Coverage   Variants Detected   Potentially Causal Variants
1  12,880,356  20,476,391  7.60  86  84.3%  166  0
1  26,909,765  34,686,130  7.78  102  91.0%  43  2
3  126,380,804  127,502,549  1.12  7  97.9%  5  0
5  98,552,184  99,968,045  1.42  1  100%  0  0
6  34,502,022  36,226,525  1.72  28  95.9%  16  0
7  64,926,823  66,464,764  1.54  10  82.7%  3  0
8  48,639,976  49,656,604  1.02  5  80.5%  3  0
8  85,802,488  86,990,451  1.19  8  89.7%  4  0
11  47,976,882  51,591,253  3.61  13  95.9%  32  0
11  54,794,237  55,943,322  1.15  25  89.4%  52  0
For each homozygous region shared between all three siblings, the table shows genomic coordinates (UCSC Genome Browser hg19), the length (Mb), the number of CCDS genes that lie in the region, the percentage of CCDS bases (including UTRs) covered by exome sequencing, the number of variants detected in that region, and the number of potentially causal variants that remained after filtration, as detailed in the methods. The following abbreviation is used: Chr, chromosome.