The URLs for data presented herein are as follows:1000 Genomes, http://www.1000genomes.org/ Complete Genomics, http://www.completegenomics.com/public-data/69-Genomes/ dbSNP, http://www.ncbi.nlm.nih.gov/projects/SNP/ MERLIN, http://www.sph.umich.edu/csg/abecasis/merlin/index.html MutationTaster, http://www.mutationtaster.org/ NHLBI GO Exome Sequencing Project, https://esp.gs.washington.edu/drupal/ OMIM, http://www.omim.org PolyPhen-2, http://genetics.bwh.harvard.edu/pph2/ PROVEAN, http://provean.jcvi.org/index.php RefSeq, http://www.ncbi.nlm.nih.gov/refseq/ SIFT, http://sift.jcvi.org/ UCSC Genome Browser, http://genome.ucsc.edu/