The differentially expressed genes list was uploaded to construct and visualize the representative networks for each group using GeneGo MetaCore™ in ArrayTrack System (FDA, USA). .The networks were generated as the interactions (edges) connecting the input genes (nodes). The edges were derived from the genes which had annotated functional interactions in GeneGo database. Three algorithms were used to analyze the properties of the networks: (1) the direct interaction algorithm to map direct gene-gene interactions; (2) the shortest path algorithm to map the shortest path for interaction between differentially expressed genes; and (3) the analyze algorithm to deduce top scoring processes that are regulated by differentially expressed genes [19]. Only the genes in the upload list were contained in the network.