From network N1, we will infer the rewired network N2 corresponding to cancer cell lines by fitting simulated data to the cancer specific dataset. To this end, we adopt Genetic Algorithm for multiple generations to search for the most likely network rewiring events and collected 50 rewired networks in each generations along with corresponding scores. The Genetic Algorithm performed rewiring on the basic apoptotic network of Figure 1. The comparison for simulated data from network N1 and Yaffe's data for control treatments using Genetic Algorithm, before and after rewiring event in network N1, is shown in Figure 3 and 4.