d  d t   A K T = - A K T   ⋅ r c  18   + H E R 2   ⋅ r c  20   ,   d  d t   p 53 = - p 53   ⋅ r c  10   + A K T   ⋅ | r c  18   - p 53   ⋅ r c  27   ,