Evolutionary information, one of the most import kinds of information in protein functionality annotation in biological analysis, has been widely used in many studies [21,60-63]. In this study, evolutionary information in forms of PSSM profile of every protein sequence is obtained by running the PSI-BLAST [64] program to search the non-redundant (NR) database through three iteration with 0.001 as the E-value cutoff for multiple sequence alignment. The final PSSM profile is a matrix with dimension of L*20 (excluding dummy residue X), which can depicted as follows: