Additional files
Additional file 1   Appendix I. Derivation of p 1-model for directed network.
Additional file 2   Table S1. All 11,515 drug-resistant gene-pairs found in GSE38376.
Additional file 3   Table S2. All 1,083 (841 distinct) cross-talks found between EGFR and other 23 signaling pathways from Reactome database.
Additional file 4   Table S3. All 2,179 (1,050 distinct) cross-talks found between ErbB and other 34 signaling pathways from KEGG database.
Additional file 5   Table S4. All 3,084 (876 distinct) cross-talks found between ErbB and other 62 signaling pathways from WikiPathway database.
Additional file 6   Table S5. 104 drug-resistant cross-talks found between EGFR and other 23 signaling pathways from Reactome database [GSE38376].
Additional file 7   Table S6. 188 drug-resistant cross-talks found between ErbB and other 34 signaling pathways from KEGG database [GSE38376].
Additional file 8   Table S7. 299 drug-resistant cross-talks found between ErbB and other 62 signaling pathways from WikiPathway database [GSE38376].
Additional file 9   Table S8. 168 selected cross-talks which associated EGFR (or ErbB) signaling pathways with 6 other signaling pathways that were found in at least two different pathway analyses (i.e. Reactome and KEGG, or KEGG and WikiPathway, or Reactome and WikiPathway) [GSE38376].
Additional file 10   Table S9. All 10,811 drug-resistant gene-pairs found in GSE16179.
Additional file 11   Table S10. 83 drug-resistant cross-talks found between EGFR and other 23 signaling pathways from Reactome database [GSE16179].
Additional file 12   Table S11. 133 drug-resistant cross-talks found between ErbB and other 34 signaling pathways from KEGG database [GSE16179].
Additional file 13   Table S12. 278 drug-resistant cross-talks found between ErbB and other 62 signaling pathways from WikiPathway database [GSE16179].
Additional file 14   Table S13. 86 drug-resistant cross-talks found in all Reactome, KEGG and WikiPathway analyses where both genes in a particular cross-talk was up-regulated in resistant conditions but down-regulated in parental conditions [GSE16179].
Additional file 15   Table S14. 401 cross-talks from Reactome, KEGG and WikiPathway analyses where the genes are dysregulated in parental treatment vs parental basal condition, and reversely changed in resistant basal + resistant treatment vs parental basal condition [GSE16179].