Table 3  Comparative results between primary dataset (SKBR3 cell-line, GSE38376) and validation dataset (BT474 cell-line, GSE16179)
Pathway name  Found in Pathway source  Found in Pathway source  Common cross-talks in both Studies  ¶
(GSE38376)  (GSE16179)
Notch Signaling Reactome, Reactome,  MAP2K4::NOTCH1
KEGG, KEGG,
WikiPathway WikiPathway
GPCR signaling Reactome, Reactome,  CBL::TSHR
WikiPathway WikiPathway  FGFR1::TSHR
PDGFRA::GNAQ
KIT::TSHR
LCK::TSHR
MDM2::TSHR
PDGFRA::TSHR
WNT Signaling Reactome, Reactome,  AKT2::CCND2
KEGG, KEGG,  MAP2K4::CCND2
WikiPathway WikiPathway  MAP2K4::TP53
MDM2::MAP2K4
Insulin (IGF1R) Signaling Reactome, Reactome,  MDM2::MAP2K4
WikiPathway WikiPathway  TP53::MAP2K4
TGF- β Signaling Reactome, Reactome,  MDM2::TFE3
WikiPathway KEGG,  TP53::TFE3
WikiPathway
MAPK signaling KEGG, KEGG, MDM2::MAP2K4
WikiPathway WikiPathway
¶These common cross-talks were found using the primary dataset (104, 188 and 299 cross-talks from Reactome, KEGG and WikiPathway databases, respectively) and validation datasets (83, 133 and 277 cross-talks from Reactome, KEGG and WikiPathway databases, respectively). Cross-talks mentioned with Bold face are those consistent with our hypothesis that both genes in the particular cross-talk are up-regulated in resistant conditions but down-regulated in parental conditions.