Additional file 1:   Detailed information about model i CY1106.
Additional file 2:   Shared reactions between Vongsangnak’s model and i CY1106 (not including transport and exchange reactions, no compartments information).
Additional file 3:   Result of essential genes identified by FBA using minimum growth medium and yeast extract medium.
Additional file 4:   Simulation result for the capability of usage different carbon and nitrogen sources for i CY1106.
Additional file 5:   a Figure for the robustness analysis about oxygen and ARA. b Figure about the acetyl-CoA consumption pathways in iCY1106. c Figure for the robustness analysis about glutamate and ARA.
Additional file 6:   FBA simulation result for the reactions involving NADPH at different ARA levels.
Additional file 7:   Biomass composition information for M. alpina.