3.2.1  Angry
Apart from earlier and larger orbitofrontal activation in controls (75–125 ms; Fig. 2A), relative to adolescents with ASD, the other early activations (50–175 ms) in the presence of angry faces were all larger in the ASD group. These activations were lateralized to the left hemisphere, including the inferior frontal, inferior parietal and particularly the middle temporal areas. These latter two regions also showed greater activation in the ASD group later in the time-course: inferior parietal (275–325 ms) and middle temporal (350–400 ms) gyri. Otherwise to angry faces, there was significantly greater activity in the typically developing adolescents from 150 to 375 ms, involving the bilateral middle and orbital frontal areas, right middle temporal (250–350 ms), left ACC (225–275 ms; Fig. 2B), as well as right inferior temporal and supramarginal gyri (200–250 ms), and right posterior cingulate (325–375 ms; Fig. 2C).