Sequencing Data
For estimation of site-frequency spectra (SFSs) and sequence-data-based FST, we used the exome sequencing data generated by Moltke et al.8 from the 18 parents of nine trios of Greenlanders with no Danish ancestry from Qaanaaq (three trios), Tasiilaq villages (five trios), and Upernavik villages (one trio). Additionally, we downloaded 18 unrelated HapMap samples from four different populations (CEU, JPT, CHB, and YRI) from 1000 Genomes.25 For the exome data, the extended target region for Agilent SureSelect spanned 75 Mb. These regions were used for both the whole-genome sequencing data from 1000 Genomes and the exome sequencing data.