Authors’ contributions UH planned and performed most of the experiments and prepared the manuscript. RK was responsible for the in silico genomic analyses, TEP for the immunological and TL for the growth inhibition experiments; RK, TEP and TL also wrote sections of the manuscript. KH and JB participated in performing bacterial adhesion and ETEC binding inhibition experiments, HS had an accessory role in the management of the genomic data. SÅJ participated in the detection and expression analysis of slp genes and performed approximately half of the cloning and heterologous expression work. AP supervised and designed the study and participated in writing. All authors read and approved the final manuscript.