Highlights
•  GADD45β is a critical mediator of the NF-κB antiapoptotic function in MM •  GADD45β binds to MKK7 and promotes MM cell survival by blocking MKK7/JNK signaling •  GADD45β/MKK7 inhibitors display potent activity against MM, in vitro and in vivo •  GADD45β/MKK7 inhibitors are far more cancer selective than IKK/NF-κB inhibitors

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