Cellular Assays
Lentiviral infections were performed using pLentiLox.3.7, as described by Mauro et al. (2011). Enhanced GFP (eGFP)+ cells were purified, when necessary, by fluorescence-activated cell sorting. [3H]Thymidine incorporation and trypan blue exclusion assays were performed using standard methods (Mauro et al., 2011). IC50 values were defined as the mean concentration of compound inducing 50% inhibition of cell viability relative to the viability in the untreated cultures. Apoptosis analyses were performed using propidium iodide (PI) staining, as described by Mauro et al. (2011). Additional details are provided in Supplemental Experimental Procedures.