In parallel with overexpression approaches, independent research groups have adopted genetic ablation to generate several germline CART knockout murine models, to determine effects of CART depletion on feeding behavior and metabolism. General consistency has been demonstrated between results from the literature and in-house data from our novel CART KO model, supporting CART as a satiety factor. Collectively, the phenotypic effects of CART deficiency from birth, although inconsistent across studies, display promotion toward positive energy balance. Extended findings stemming from our novel KO model also denote that CART deficiency may confer an advantage in body weight conservation during starvation, potentially associated with an improved stress response attributable to an altered anxiety-related cascade involving the CART system.