PMC:4195273 / 31275-36230 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4195273","sourcedb":"PMC","sourceid":"4195273","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4195273","text":"Peripheral CART in the regulation of energy homeostasis\nThe proposed physiological role of CART as an endogenous anorexigenic factor was originally deduced from the inhibition of food consumption observed in animal models following hypothalamic or intracerebroventricular administration of CART-derived peptides (Kristensen et al., 1998; Vrang et al., 1999b; Larsen et al., 2000; Volkoff and Peter, 2000; Aja et al., 2001a,b; Stanley et al., 2001; Nakhate et al., 2011, 2013). Based on the dual involvement in both hypothalamic modulation of feeding behavior and autonomic control of gastrointestinal functions common to many neuropeptides, considerable efforts have subsequently been devoted to the investigation of CART-mediated effects in the enteric nervous system (ENS) (Couceyro et al., 1998; Kuhar and Yoho, 1999; Murphy et al., 2000; Okumura et al., 2000; Ekblad et al., 2003; Ellis and Mawe, 2003; Smedh and Moran, 2003; Tebbe et al., 2004). Extensive CART expression has been characterized in the ENS of diverse mammals by in situ hybridization (Ekblad et al., 2003) and immunoassays (Couceyro et al., 1998; Kuhar and Yoho, 1999; Murphy et al., 2000; Ellis and Mawe, 2003; Kasacka et al., 2012), affirming the presence of CART mRNA and peptides in nerve cell bodies and fibers innervating the stomach, small and large intestines of the gastrointestinal tract (Ekblad, 2006), particularly within the neuroendocrine cells and myenteric plexus (Kasacka et al., 2012). Such brain-gut CART expression suggests that CNS control of feeding and satiety may be coordinated with local gastric CART-induced effects to produce an integrated regulation of body weight. This is supported by the central CART immunoreactivity profile, which depicts concentrated expression at the hypothalamic nuclei (Spiess et al., 1981; Douglass et al., 1995; Gautvik et al., 1996; Couceyro et al., 1997; Koylu et al., 1997; Smith et al., 1999; Hubert and Kuhar, 2005, 2008; Dominguez, 2006; Vrang, 2006) constituting major relays linking the sensory, motor and limbic areas between forebrain and hindbrain through widespread reciprocal networks, orchestrating autonomic, endocrine and behavioral activities (Fekete et al., 2000; Balkan et al., 2001; Williams et al., 2001; Tebbe et al., 2004). Specifically, anatomical implications of CART indicated by enteric CART expression in digestive function have been further indicated by CART immunoreactivity at the hypothalamic Arc and PVN neurons, as well as brainstem nuclei such as NTS and parabrachial nucleus (PBN), both involved in the efferent and afferent control of GI function through neuropeptidergic mechanisms engaging the complex neuroendocrine and autonomic pathways (Kristensen et al., 1998; Fekete et al., 2000; Aja et al., 2001b; Stanley et al., 2001; Zheng et al., 2001; Tebbe et al., 2003, 2004). In addition, CART expression in the cholinergic neurons of the myenteric plexus and the pancreatic islets further denoted the potential gastric effects of CART conducted via peripheral receptor targets composing the peripheral cholinergic pathways (Couceyro et al., 1998; Jensen et al., 1999; Ekblad et al., 2003; Tebbe et al., 2004; Wierup et al., 2004).\nThe precise functions of CART peptides released by enteric CART-expressing neurons in the ENS are yet to be determined (Ekblad, 2006). There has been a lack of direct evidence regarding a role of locally produced CART in classical neurotransmission within the GI tract, where intestinal motility as measured by contractile or relaxatory responses was unaffected by CART peptide application when motor activity studies were performed in vitro on muscle strips from stomach, small and large intestine (Ekblad et al., 2003). Notably, exceptions to the above may include specific CART-evoked colonic responses, such as the attenuation of nitric oxide-induced intestinal relaxation (Ekblad et al., 2003; Ekblad, 2006), as well as the apparent stimulation of colonic transit, an indirect measure of colonic motor function (Tebbe et al., 2004). In spite of the confined documentation of CART involvement in brain-gut interaction and the indeterminate functional role of enteric CART, accumulating evidence propose a role of CART in intestinal adaptation, where the survival and maintenance of enteric neurons is promoted (Ekblad et al., 2003; Ekblad, 2006). Such neuroprotective property (Ekblad, 2006; Zhang et al., 2012) and intestinal plasticity has been inferred from upregulated CART expression and increased CART-expressing neurons in atrophic intestine and cultured myenteric neurons respectively, conditions indicative of neuronal stress or injury (Ekblad et al., 2003; Ekblad, 2006). In sum, gastric involvement of CART has been evident through discrete histological and physiological experiments, whilst further detailed characterization of distribution and functions may contribute to a comprehensive understanding of the specific roles of enteric CART.","divisions":[{"label":"title","span":{"begin":0,"end":55}},{"label":"p","span":{"begin":56,"end":3197}}],"tracks":[{"project":"TEST0","denotations":[{"id":"25352770-233-241-357511","span":{"begin":332,"end":336},"obj":"[\"9590691\"]"},{"id":"25352770-226-234-357513","span":{"begin":374,"end":378},"obj":"[\"11156435\"]"},{"id":"25352770-234-242-357514","span":{"begin":399,"end":403},"obj":"[\"11134597\"]"},{"id":"25352770-234-242-357517","span":{"begin":442,"end":446},"obj":"[\"11223006\"]"},{"id":"25352770-232-240-357518","span":{"begin":464,"end":468},"obj":"[\"21060312\"]"},{"id":"25352770-225-233-357519","span":{"begin":470,"end":474},"obj":"[\"23933097\"]"},{"id":"25352770-234-242-357520","span":{"begin":793,"end":797},"obj":"[\"9704875\"]"},{"id":"25352770-234-242-357521","span":{"begin":815,"end":819},"obj":"[\"10420164\"]"},{"id":"25352770-235-243-357522","span":{"begin":836,"end":840},"obj":"[\"10974659\"]"},{"id":"25352770-232-240-357523","span":{"begin":858,"end":862},"obj":"[\"10919272\"]"},{"id":"25352770-225-233-357524","span":{"begin":879,"end":883},"obj":"[\"14507354\"]"},{"id":"25352770-234-242-357525","span":{"begin":901,"end":905},"obj":"[\"12768408\"]"},{"id":"25352770-231-239-357526","span":{"begin":924,"end":928},"obj":"[\"12468444\"]"},{"id":"25352770-230-238-357527","span":{"begin":944,"end":948},"obj":"[\"15306004\"]"},{"id":"25352770-120-128-357528","span":{"begin":1071,"end":1075},"obj":"[\"14507354\"]"},{"id":"25352770-161-169-357529","span":{"begin":1112,"end":1116},"obj":"[\"9704875\"]"},{"id":"25352770-183-191-357530","span":{"begin":1134,"end":1138},"obj":"[\"10420164\"]"},{"id":"25352770-204-212-357531","span":{"begin":1155,"end":1159},"obj":"[\"10974659\"]"},{"id":"25352770-226-234-357532","span":{"begin":1177,"end":1181},"obj":"[\"12768408\"]"},{"id":"25352770-233-241-357533","span":{"begin":1199,"end":1203},"obj":"[\"22257587\"]"},{"id":"25352770-231-239-357534","span":{"begin":1378,"end":1382},"obj":"[\"16759747\"]"},{"id":"25352770-231-239-357535","span":{"begin":1468,"end":1472},"obj":"[\"22257587\"]"},{"id":"25352770-145-153-357536","span":{"begin":1811,"end":1815},"obj":"[\"7225368\"]"},{"id":"25352770-168-176-357537","span":{"begin":1834,"end":1838},"obj":"[\"7891182\"]"},{"id":"25352770-190-198-357538","span":{"begin":1856,"end":1860},"obj":"[\"8710940\"]"},{"id":"25352770-213-221-357539","span":{"begin":1879,"end":1883},"obj":"[\"9243343\"]"},{"id":"25352770-233-241-357540","span":{"begin":1899,"end":1903},"obj":"[\"9419833\"]"},{"id":"25352770-235-243-357541","span":{"begin":1919,"end":1923},"obj":"[\"10235641\"]"},{"id":"25352770-222-230-357542","span":{"begin":1943,"end":1947},"obj":"[\"15978559\"]"},{"id":"25352770-228-236-357543","span":{"begin":1949,"end":1953},"obj":"[\"18314190\"]"},{"id":"25352770-230-238-357544","span":{"begin":1966,"end":1970},"obj":"[\"16716454\"]"},{"id":"25352770-235-243-357545","span":{"begin":1979,"end":1983},"obj":"[\"16765484\"]"},{"id":"25352770-232-240-357546","span":{"begin":2204,"end":2208},"obj":"[\"11125000\"]"},{"id":"25352770-227-235-357547","span":{"begin":2225,"end":2229},"obj":"[\"11602226\"]"},{"id":"25352770-229-237-357548","span":{"begin":2248,"end":2252},"obj":"[\"11790431\"]"},{"id":"25352770-230-238-357549","span":{"begin":2268,"end":2272},"obj":"[\"15306004\"]"},{"id":"25352770-232-240-357550","span":{"begin":2727,"end":2731},"obj":"[\"9590691\"]"},{"id":"25352770-234-242-357551","span":{"begin":2748,"end":2752},"obj":"[\"11125000\"]"},{"id":"25352770-229-237-357553","span":{"begin":2789,"end":2793},"obj":"[\"11223006\"]"},{"id":"25352770-233-241-357554","span":{"begin":2809,"end":2813},"obj":"[\"11277984\"]"},{"id":"25352770-232-240-357555","span":{"begin":2829,"end":2833},"obj":"[\"12855401\"]"},{"id":"25352770-235-243-357556","span":{"begin":2835,"end":2839},"obj":"[\"15306004\"]"},{"id":"25352770-234-242-357557","span":{"begin":3108,"end":3112},"obj":"[\"9704875\"]"},{"id":"25352770-231-239-357558","span":{"begin":3129,"end":3133},"obj":"[\"10214934\"]"},{"id":"25352770-235-243-357559","span":{"begin":3150,"end":3154},"obj":"[\"14507354\"]"},{"id":"25352770-229-237-357560","span":{"begin":3170,"end":3174},"obj":"[\"15306004\"]"},{"id":"25352770-235-243-357561","span":{"begin":3191,"end":3195},"obj":"[\"14729868\"]"},{"id":"25352770-128-136-357562","span":{"begin":3326,"end":3330},"obj":"[\"16759747\"]"},{"id":"25352770-228-236-357563","span":{"begin":3713,"end":3717},"obj":"[\"14507354\"]"},{"id":"25352770-171-179-357564","span":{"begin":3891,"end":3895},"obj":"[\"14507354\"]"},{"id":"25352770-185-193-357565","span":{"begin":3905,"end":3909},"obj":"[\"16759747\"]"},{"id":"25352770-235-243-357566","span":{"begin":4029,"end":4033},"obj":"[\"15306004\"]"},{"id":"25352770-233-241-357567","span":{"begin":4328,"end":4332},"obj":"[\"14507354\"]"},{"id":"25352770-234-242-357568","span":{"begin":4342,"end":4346},"obj":"[\"16759747\"]"},{"id":"25352770-39-47-357569","span":{"begin":4388,"end":4392},"obj":"[\"16759747\"]"},{"id":"25352770-59-67-357570","span":{"begin":4408,"end":4412},"obj":"[\"22077697\"]"},{"id":"25352770-234-242-357571","span":{"begin":4663,"end":4667},"obj":"[\"14507354\"]"},{"id":"25352770-233-241-357572","span":{"begin":4677,"end":4681},"obj":"[\"16759747\"]"}],"attributes":[{"subj":"25352770-233-241-357511","pred":"source","obj":"TEST0"},{"subj":"25352770-226-234-357513","pred":"source","obj":"TEST0"},{"subj":"25352770-234-242-357514","pred":"source","obj":"TEST0"},{"subj":"25352770-234-242-357517","pred":"source","obj":"TEST0"},{"subj":"25352770-232-240-357518","pred":"source","obj":"TEST0"},{"subj":"25352770-225-233-357519","pred":"source","obj":"TEST0"},{"subj":"25352770-234-242-357520","pred":"source","obj":"TEST0"},{"subj":"25352770-234-242-357521","pred":"source","obj":"TEST0"},{"subj":"25352770-235-243-357522","pred":"source","obj":"TEST0"},{"subj":"25352770-232-240-357523","pred":"source","obj":"TEST0"},{"subj":"25352770-225-233-357524","pred":"source","obj":"TEST0"},{"subj":"25352770-234-242-357525","pred":"source","obj":"TEST0"},{"subj":"25352770-231-239-357526","pred":"source","obj":"TEST0"},{"subj":"25352770-230-238-357527","pred":"source","obj":"TEST0"},{"subj":"25352770-120-128-357528","pred":"source","obj":"TEST0"},{"subj":"25352770-161-169-357529","pred":"source","obj":"TEST0"},{"subj":"25352770-183-191-357530","pred":"source","obj":"TEST0"},{"subj":"25352770-204-212-357531","pred":"source","obj":"TEST0"},{"subj":"25352770-226-234-357532","pred":"source","obj":"TEST0"},{"subj":"25352770-233-241-357533","pred":"source","obj":"TEST0"},{"subj":"25352770-231-239-357534","pred":"source","obj":"TEST0"},{"subj":"25352770-231-239-357535","pred":"source","obj":"TEST0"},{"subj":"25352770-145-153-357536","pred":"source","obj":"TEST0"},{"subj":"25352770-168-176-357537","pred":"source","obj":"TEST0"},{"subj":"25352770-190-198-357538","pred":"source","obj":"TEST0"},{"subj":"25352770-213-221-357539","pred":"source","obj":"TEST0"},{"subj":"25352770-233-241-357540","pred":"source","obj":"TEST0"},{"subj":"25352770-235-243-357541","pred":"source","obj":"TEST0"},{"subj":"25352770-222-230-357542","pred":"source","obj":"TEST0"},{"subj":"25352770-228-236-357543","pred":"source","obj":"TEST0"},{"subj":"25352770-230-238-357544","pred":"source","obj":"TEST0"},{"subj":"25352770-235-243-357545","pred":"source","obj":"TEST0"},{"subj":"25352770-232-240-357546","pred":"source","obj":"TEST0"},{"subj":"25352770-227-235-357547","pred":"source","obj":"TEST0"},{"subj":"25352770-229-237-357548","pred":"source","obj":"TEST0"},{"subj":"25352770-230-238-357549","pred":"source","obj":"TEST0"},{"subj":"25352770-232-240-357550","pred":"source","obj":"TEST0"},{"subj":"25352770-234-242-357551","pred":"source","obj":"TEST0"},{"subj":"25352770-229-237-357553","pred":"source","obj":"TEST0"},{"subj":"25352770-233-241-357554","pred":"source","obj":"TEST0"},{"subj":"25352770-232-240-357555","pred":"source","obj":"TEST0"},{"subj":"25352770-235-243-357556","pred":"source","obj":"TEST0"},{"subj":"25352770-234-242-357557","pred":"source","obj":"TEST0"},{"subj":"25352770-231-239-357558","pred":"source","obj":"TEST0"},{"subj":"25352770-235-243-357559","pred":"source","obj":"TEST0"},{"subj":"25352770-229-237-357560","pred":"source","obj":"TEST0"},{"subj":"25352770-235-243-357561","pred":"source","obj":"TEST0"},{"subj":"25352770-128-136-357562","pred":"source","obj":"TEST0"},{"subj":"25352770-228-236-357563","pred":"source","obj":"TEST0"},{"subj":"25352770-171-179-357564","pred":"source","obj":"TEST0"},{"subj":"25352770-185-193-357565","pred":"source","obj":"TEST0"},{"subj":"25352770-235-243-357566","pred":"source","obj":"TEST0"},{"subj":"25352770-233-241-357567","pred":"source","obj":"TEST0"},{"subj":"25352770-234-242-357568","pred":"source","obj":"TEST0"},{"subj":"25352770-39-47-357569","pred":"source","obj":"TEST0"},{"subj":"25352770-59-67-357570","pred":"source","obj":"TEST0"},{"subj":"25352770-234-242-357571","pred":"source","obj":"TEST0"},{"subj":"25352770-233-241-357572","pred":"source","obj":"TEST0"}]},{"project":"0_colil","denotations":[{"id":"25352770-9590691-357511","span":{"begin":332,"end":336},"obj":"9590691"},{"id":"25352770-11156435-357513","span":{"begin":374,"end":378},"obj":"11156435"},{"id":"25352770-11134597-357514","span":{"begin":399,"end":403},"obj":"11134597"},{"id":"25352770-11223006-357517","span":{"begin":442,"end":446},"obj":"11223006"},{"id":"25352770-21060312-357518","span":{"begin":464,"end":468},"obj":"21060312"},{"id":"25352770-23933097-357519","span":{"begin":470,"end":474},"obj":"23933097"},{"id":"25352770-9704875-357520","span":{"begin":793,"end":797},"obj":"9704875"},{"id":"25352770-10420164-357521","span":{"begin":815,"end":819},"obj":"10420164"},{"id":"25352770-10974659-357522","span":{"begin":836,"end":840},"obj":"10974659"},{"id":"25352770-10919272-357523","span":{"begin":858,"end":862},"obj":"10919272"},{"id":"25352770-14507354-357524","span":{"begin":879,"end":883},"obj":"14507354"},{"id":"25352770-12768408-357525","span":{"begin":901,"end":905},"obj":"12768408"},{"id":"25352770-12468444-357526","span":{"begin":924,"end":928},"obj":"12468444"},{"id":"25352770-15306004-357527","span":{"begin":944,"end":948},"obj":"15306004"},{"id":"25352770-14507354-357528","span":{"begin":1071,"end":1075},"obj":"14507354"},{"id":"25352770-9704875-357529","span":{"begin":1112,"end":1116},"obj":"9704875"},{"id":"25352770-10420164-357530","span":{"begin":1134,"end":1138},"obj":"10420164"},{"id":"25352770-10974659-357531","span":{"begin":1155,"end":1159},"obj":"10974659"},{"id":"25352770-12768408-357532","span":{"begin":1177,"end":1181},"obj":"12768408"},{"id":"25352770-22257587-357533","span":{"begin":1199,"end":1203},"obj":"22257587"},{"id":"25352770-16759747-357534","span":{"begin":1378,"end":1382},"obj":"16759747"},{"id":"25352770-22257587-357535","span":{"begin":1468,"end":1472},"obj":"22257587"},{"id":"25352770-7225368-357536","span":{"begin":1811,"end":1815},"obj":"7225368"},{"id":"25352770-7891182-357537","span":{"begin":1834,"end":1838},"obj":"7891182"},{"id":"25352770-8710940-357538","span":{"begin":1856,"end":1860},"obj":"8710940"},{"id":"25352770-9243343-357539","span":{"begin":1879,"end":1883},"obj":"9243343"},{"id":"25352770-9419833-357540","span":{"begin":1899,"end":1903},"obj":"9419833"},{"id":"25352770-10235641-357541","span":{"begin":1919,"end":1923},"obj":"10235641"},{"id":"25352770-15978559-357542","span":{"begin":1943,"end":1947},"obj":"15978559"},{"id":"25352770-18314190-357543","span":{"begin":1949,"end":1953},"obj":"18314190"},{"id":"25352770-16716454-357544","span":{"begin":1966,"end":1970},"obj":"16716454"},{"id":"25352770-16765484-357545","span":{"begin":1979,"end":1983},"obj":"16765484"},{"id":"25352770-11125000-357546","span":{"begin":2204,"end":2208},"obj":"11125000"},{"id":"25352770-11602226-357547","span":{"begin":2225,"end":2229},"obj":"11602226"},{"id":"25352770-11790431-357548","span":{"begin":2248,"end":2252},"obj":"11790431"},{"id":"25352770-15306004-357549","span":{"begin":2268,"end":2272},"obj":"15306004"},{"id":"25352770-9590691-357550","span":{"begin":2727,"end":2731},"obj":"9590691"},{"id":"25352770-11125000-357551","span":{"begin":2748,"end":2752},"obj":"11125000"},{"id":"25352770-11223006-357553","span":{"begin":2789,"end":2793},"obj":"11223006"},{"id":"25352770-11277984-357554","span":{"begin":2809,"end":2813},"obj":"11277984"},{"id":"25352770-12855401-357555","span":{"begin":2829,"end":2833},"obj":"12855401"},{"id":"25352770-15306004-357556","span":{"begin":2835,"end":2839},"obj":"15306004"},{"id":"25352770-9704875-357557","span":{"begin":3108,"end":3112},"obj":"9704875"},{"id":"25352770-10214934-357558","span":{"begin":3129,"end":3133},"obj":"10214934"},{"id":"25352770-14507354-357559","span":{"begin":3150,"end":3154},"obj":"14507354"},{"id":"25352770-15306004-357560","span":{"begin":3170,"end":3174},"obj":"15306004"},{"id":"25352770-14729868-357561","span":{"begin":3191,"end":3195},"obj":"14729868"},{"id":"25352770-16759747-357562","span":{"begin":3326,"end":3330},"obj":"16759747"},{"id":"25352770-14507354-357563","span":{"begin":3713,"end":3717},"obj":"14507354"},{"id":"25352770-14507354-357564","span":{"begin":3891,"end":3895},"obj":"14507354"},{"id":"25352770-16759747-357565","span":{"begin":3905,"end":3909},"obj":"16759747"},{"id":"25352770-15306004-357566","span":{"begin":4029,"end":4033},"obj":"15306004"},{"id":"25352770-14507354-357567","span":{"begin":4328,"end":4332},"obj":"14507354"},{"id":"25352770-16759747-357568","span":{"begin":4342,"end":4346},"obj":"16759747"},{"id":"25352770-16759747-357569","span":{"begin":4388,"end":4392},"obj":"16759747"},{"id":"25352770-22077697-357570","span":{"begin":4408,"end":4412},"obj":"22077697"},{"id":"25352770-14507354-357571","span":{"begin":4663,"end":4667},"obj":"14507354"},{"id":"25352770-16759747-357572","span":{"begin":4677,"end":4681},"obj":"16759747"}],"attributes":[{"subj":"25352770-9590691-357511","pred":"source","obj":"0_colil"},{"subj":"25352770-11156435-357513","pred":"source","obj":"0_colil"},{"subj":"25352770-11134597-357514","pred":"source","obj":"0_colil"},{"subj":"25352770-11223006-357517","pred":"source","obj":"0_colil"},{"subj":"25352770-21060312-357518","pred":"source","obj":"0_colil"},{"subj":"25352770-23933097-357519","pred":"source","obj":"0_colil"},{"subj":"25352770-9704875-357520","pred":"source","obj":"0_colil"},{"subj":"25352770-10420164-357521","pred":"source","obj":"0_colil"},{"subj":"25352770-10974659-357522","pred":"source","obj":"0_colil"},{"subj":"25352770-10919272-357523","pred":"source","obj":"0_colil"},{"subj":"25352770-14507354-357524","pred":"source","obj":"0_colil"},{"subj":"25352770-12768408-357525","pred":"source","obj":"0_colil"},{"subj":"25352770-12468444-357526","pred":"source","obj":"0_colil"},{"subj":"25352770-15306004-357527","pred":"source","obj":"0_colil"},{"subj":"25352770-14507354-357528","pred":"source","obj":"0_colil"},{"subj":"25352770-9704875-357529","pred":"source","obj":"0_colil"},{"subj":"25352770-10420164-357530","pred":"source","obj":"0_colil"},{"subj":"25352770-10974659-357531","pred":"source","obj":"0_colil"},{"subj":"25352770-12768408-357532","pred":"source","obj":"0_colil"},{"subj":"25352770-22257587-357533","pred":"source","obj":"0_colil"},{"subj":"25352770-16759747-357534","pred":"source","obj":"0_colil"},{"subj":"25352770-22257587-357535","pred":"source","obj":"0_colil"},{"subj":"25352770-7225368-357536","pred":"source","obj":"0_colil"},{"subj":"25352770-7891182-357537","pred":"source","obj":"0_colil"},{"subj":"25352770-8710940-357538","pred":"source","obj":"0_colil"},{"subj":"25352770-9243343-357539","pred":"source","obj":"0_colil"},{"subj":"25352770-9419833-357540","pred":"source","obj":"0_colil"},{"subj":"25352770-10235641-357541","pred":"source","obj":"0_colil"},{"subj":"25352770-15978559-357542","pred":"source","obj":"0_colil"},{"subj":"25352770-18314190-357543","pred":"source","obj":"0_colil"},{"subj":"25352770-16716454-357544","pred":"source","obj":"0_colil"},{"subj":"25352770-16765484-357545","pred":"source","obj":"0_colil"},{"subj":"25352770-11125000-357546","pred":"source","obj":"0_colil"},{"subj":"25352770-11602226-357547","pred":"source","obj":"0_colil"},{"subj":"25352770-11790431-357548","pred":"source","obj":"0_colil"},{"subj":"25352770-15306004-357549","pred":"source","obj":"0_colil"},{"subj":"25352770-9590691-357550","pred":"source","obj":"0_colil"},{"subj":"25352770-11125000-357551","pred":"source","obj":"0_colil"},{"subj":"25352770-11223006-357553","pred":"source","obj":"0_colil"},{"subj":"25352770-11277984-357554","pred":"source","obj":"0_colil"},{"subj":"25352770-12855401-357555","pred":"source","obj":"0_colil"},{"subj":"25352770-15306004-357556","pred":"source","obj":"0_colil"},{"subj":"25352770-9704875-357557","pred":"source","obj":"0_colil"},{"subj":"25352770-10214934-357558","pred":"source","obj":"0_colil"},{"subj":"25352770-14507354-357559","pred":"source","obj":"0_colil"},{"subj":"25352770-15306004-357560","pred":"source","obj":"0_colil"},{"subj":"25352770-14729868-357561","pred":"source","obj":"0_colil"},{"subj":"25352770-16759747-357562","pred":"source","obj":"0_colil"},{"subj":"25352770-14507354-357563","pred":"source","obj":"0_colil"},{"subj":"25352770-14507354-357564","pred":"source","obj":"0_colil"},{"subj":"25352770-16759747-357565","pred":"source","obj":"0_colil"},{"subj":"25352770-15306004-357566","pred":"source","obj":"0_colil"},{"subj":"25352770-14507354-357567","pred":"source","obj":"0_colil"},{"subj":"25352770-16759747-357568","pred":"source","obj":"0_colil"},{"subj":"25352770-16759747-357569","pred":"source","obj":"0_colil"},{"subj":"25352770-22077697-357570","pred":"source","obj":"0_colil"},{"subj":"25352770-14507354-357571","pred":"source","obj":"0_colil"},{"subj":"25352770-16759747-357572","pred":"source","obj":"0_colil"}]},{"project":"2_test","denotations":[{"id":"25352770-9590691-38284500","span":{"begin":332,"end":336},"obj":"9590691"},{"id":"25352770-11156435-38284502","span":{"begin":374,"end":378},"obj":"11156435"},{"id":"25352770-11134597-38284503","span":{"begin":399,"end":403},"obj":"11134597"},{"id":"25352770-11223006-38284506","span":{"begin":442,"end":446},"obj":"11223006"},{"id":"25352770-21060312-38284507","span":{"begin":464,"end":468},"obj":"21060312"},{"id":"25352770-23933097-38284508","span":{"begin":470,"end":474},"obj":"23933097"},{"id":"25352770-9704875-38284509","span":{"begin":793,"end":797},"obj":"9704875"},{"id":"25352770-10420164-38284510","span":{"begin":815,"end":819},"obj":"10420164"},{"id":"25352770-10974659-38284511","span":{"begin":836,"end":840},"obj":"10974659"},{"id":"25352770-10919272-38284512","span":{"begin":858,"end":862},"obj":"10919272"},{"id":"25352770-14507354-38284513","span":{"begin":879,"end":883},"obj":"14507354"},{"id":"25352770-12768408-38284514","span":{"begin":901,"end":905},"obj":"12768408"},{"id":"25352770-12468444-38284515","span":{"begin":924,"end":928},"obj":"12468444"},{"id":"25352770-15306004-38284516","span":{"begin":944,"end":948},"obj":"15306004"},{"id":"25352770-14507354-38284517","span":{"begin":1071,"end":1075},"obj":"14507354"},{"id":"25352770-9704875-38284518","span":{"begin":1112,"end":1116},"obj":"9704875"},{"id":"25352770-10420164-38284519","span":{"begin":1134,"end":1138},"obj":"10420164"},{"id":"25352770-10974659-38284520","span":{"begin":1155,"end":1159},"obj":"10974659"},{"id":"25352770-12768408-38284521","span":{"begin":1177,"end":1181},"obj":"12768408"},{"id":"25352770-22257587-38284522","span":{"begin":1199,"end":1203},"obj":"22257587"},{"id":"25352770-16759747-38284523","span":{"begin":1378,"end":1382},"obj":"16759747"},{"id":"25352770-22257587-38284524","span":{"begin":1468,"end":1472},"obj":"22257587"},{"id":"25352770-7225368-38284525","span":{"begin":1811,"end":1815},"obj":"7225368"},{"id":"25352770-7891182-38284526","span":{"begin":1834,"end":1838},"obj":"7891182"},{"id":"25352770-8710940-38284527","span":{"begin":1856,"end":1860},"obj":"8710940"},{"id":"25352770-9243343-38284528","span":{"begin":1879,"end":1883},"obj":"9243343"},{"id":"25352770-9419833-38284529","span":{"begin":1899,"end":1903},"obj":"9419833"},{"id":"25352770-10235641-38284530","span":{"begin":1919,"end":1923},"obj":"10235641"},{"id":"25352770-15978559-38284531","span":{"begin":1943,"end":1947},"obj":"15978559"},{"id":"25352770-18314190-38284532","span":{"begin":1949,"end":1953},"obj":"18314190"},{"id":"25352770-16716454-38284533","span":{"begin":1966,"end":1970},"obj":"16716454"},{"id":"25352770-16765484-38284534","span":{"begin":1979,"end":1983},"obj":"16765484"},{"id":"25352770-11125000-38284535","span":{"begin":2204,"end":2208},"obj":"11125000"},{"id":"25352770-11602226-38284536","span":{"begin":2225,"end":2229},"obj":"11602226"},{"id":"25352770-11790431-38284537","span":{"begin":2248,"end":2252},"obj":"11790431"},{"id":"25352770-15306004-38284538","span":{"begin":2268,"end":2272},"obj":"15306004"},{"id":"25352770-9590691-38284539","span":{"begin":2727,"end":2731},"obj":"9590691"},{"id":"25352770-11125000-38284540","span":{"begin":2748,"end":2752},"obj":"11125000"},{"id":"25352770-11223006-38284542","span":{"begin":2789,"end":2793},"obj":"11223006"},{"id":"25352770-11277984-38284543","span":{"begin":2809,"end":2813},"obj":"11277984"},{"id":"25352770-12855401-38284544","span":{"begin":2829,"end":2833},"obj":"12855401"},{"id":"25352770-15306004-38284545","span":{"begin":2835,"end":2839},"obj":"15306004"},{"id":"25352770-9704875-38284546","span":{"begin":3108,"end":3112},"obj":"9704875"},{"id":"25352770-10214934-38284547","span":{"begin":3129,"end":3133},"obj":"10214934"},{"id":"25352770-14507354-38284548","span":{"begin":3150,"end":3154},"obj":"14507354"},{"id":"25352770-15306004-38284549","span":{"begin":3170,"end":3174},"obj":"15306004"},{"id":"25352770-14729868-38284550","span":{"begin":3191,"end":3195},"obj":"14729868"},{"id":"25352770-16759747-38284551","span":{"begin":3326,"end":3330},"obj":"16759747"},{"id":"25352770-14507354-38284552","span":{"begin":3713,"end":3717},"obj":"14507354"},{"id":"25352770-14507354-38284553","span":{"begin":3891,"end":3895},"obj":"14507354"},{"id":"25352770-16759747-38284554","span":{"begin":3905,"end":3909},"obj":"16759747"},{"id":"25352770-15306004-38284555","span":{"begin":4029,"end":4033},"obj":"15306004"},{"id":"25352770-14507354-38284556","span":{"begin":4328,"end":4332},"obj":"14507354"},{"id":"25352770-16759747-38284557","span":{"begin":4342,"end":4346},"obj":"16759747"},{"id":"25352770-16759747-38284558","span":{"begin":4388,"end":4392},"obj":"16759747"},{"id":"25352770-22077697-38284559","span":{"begin":4408,"end":4412},"obj":"22077697"},{"id":"25352770-14507354-38284560","span":{"begin":4663,"end":4667},"obj":"14507354"},{"id":"25352770-16759747-38284561","span":{"begin":4677,"end":4681},"obj":"16759747"}],"attributes":[{"subj":"25352770-9590691-38284500","pred":"source","obj":"2_test"},{"subj":"25352770-11156435-38284502","pred":"source","obj":"2_test"},{"subj":"25352770-11134597-38284503","pred":"source","obj":"2_test"},{"subj":"25352770-11223006-38284506","pred":"source","obj":"2_test"},{"subj":"25352770-21060312-38284507","pred":"source","obj":"2_test"},{"subj":"25352770-23933097-38284508","pred":"source","obj":"2_test"},{"subj":"25352770-9704875-38284509","pred":"source","obj":"2_test"},{"subj":"25352770-10420164-38284510","pred":"source","obj":"2_test"},{"subj":"25352770-10974659-38284511","pred":"source","obj":"2_test"},{"subj":"25352770-10919272-38284512","pred":"source","obj":"2_test"},{"subj":"25352770-14507354-38284513","pred":"source","obj":"2_test"},{"subj":"25352770-12768408-38284514","pred":"source","obj":"2_test"},{"subj":"25352770-12468444-38284515","pred":"source","obj":"2_test"},{"subj":"25352770-15306004-38284516","pred":"source","obj":"2_test"},{"subj":"25352770-14507354-38284517","pred":"source","obj":"2_test"},{"subj":"25352770-9704875-38284518","pred":"source","obj":"2_test"},{"subj":"25352770-10420164-38284519","pred":"source","obj":"2_test"},{"subj":"25352770-10974659-38284520","pred":"source","obj":"2_test"},{"subj":"25352770-12768408-38284521","pred":"source","obj":"2_test"},{"subj":"25352770-22257587-38284522","pred":"source","obj":"2_test"},{"subj":"25352770-16759747-38284523","pred":"source","obj":"2_test"},{"subj":"25352770-22257587-38284524","pred":"source","obj":"2_test"},{"subj":"25352770-7225368-38284525","pred":"source","obj":"2_test"},{"subj":"25352770-7891182-38284526","pred":"source","obj":"2_test"},{"subj":"25352770-8710940-38284527","pred":"source","obj":"2_test"},{"subj":"25352770-9243343-38284528","pred":"source","obj":"2_test"},{"subj":"25352770-9419833-38284529","pred":"source","obj":"2_test"},{"subj":"25352770-10235641-38284530","pred":"source","obj":"2_test"},{"subj":"25352770-15978559-38284531","pred":"source","obj":"2_test"},{"subj":"25352770-18314190-38284532","pred":"source","obj":"2_test"},{"subj":"25352770-16716454-38284533","pred":"source","obj":"2_test"},{"subj":"25352770-16765484-38284534","pred":"source","obj":"2_test"},{"subj":"25352770-11125000-38284535","pred":"source","obj":"2_test"},{"subj":"25352770-11602226-38284536","pred":"source","obj":"2_test"},{"subj":"25352770-11790431-38284537","pred":"source","obj":"2_test"},{"subj":"25352770-15306004-38284538","pred":"source","obj":"2_test"},{"subj":"25352770-9590691-38284539","pred":"source","obj":"2_test"},{"subj":"25352770-11125000-38284540","pred":"source","obj":"2_test"},{"subj":"25352770-11223006-38284542","pred":"source","obj":"2_test"},{"subj":"25352770-11277984-38284543","pred":"source","obj":"2_test"},{"subj":"25352770-12855401-38284544","pred":"source","obj":"2_test"},{"subj":"25352770-15306004-38284545","pred":"source","obj":"2_test"},{"subj":"25352770-9704875-38284546","pred":"source","obj":"2_test"},{"subj":"25352770-10214934-38284547","pred":"source","obj":"2_test"},{"subj":"25352770-14507354-38284548","pred":"source","obj":"2_test"},{"subj":"25352770-15306004-38284549","pred":"source","obj":"2_test"},{"subj":"25352770-14729868-38284550","pred":"source","obj":"2_test"},{"subj":"25352770-16759747-38284551","pred":"source","obj":"2_test"},{"subj":"25352770-14507354-38284552","pred":"source","obj":"2_test"},{"subj":"25352770-14507354-38284553","pred":"source","obj":"2_test"},{"subj":"25352770-16759747-38284554","pred":"source","obj":"2_test"},{"subj":"25352770-15306004-38284555","pred":"source","obj":"2_test"},{"subj":"25352770-14507354-38284556","pred":"source","obj":"2_test"},{"subj":"25352770-16759747-38284557","pred":"source","obj":"2_test"},{"subj":"25352770-16759747-38284558","pred":"source","obj":"2_test"},{"subj":"25352770-22077697-38284559","pred":"source","obj":"2_test"},{"subj":"25352770-14507354-38284560","pred":"source","obj":"2_test"},{"subj":"25352770-16759747-38284561","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"TEST0","color":"#99ec93","default":true},{"id":"0_colil","color":"#ec93b3"},{"id":"2_test","color":"#93cdec"}]}]}}