As part of the multifactorial concept of osteosarcopenic obesity, future studies on the relationship between both psychological and physical fatigue in the development and exacerbation of this syndrome must be explored. Fatigue is a behavioral marker for reduced ability to adapt to stressors, leading to reduced physical function and poorer quality of life. Reductions in fatigue by using holistic measures may be proven beneficial as a potential countermeasure for osteosarcopenic obesity [110].