While obesity is clearly a multifactorial condition, the primary causes appear to be related to an excess energy consumption, low levels of physical activity, and high genetic susceptibility [45]. An increase in body fat from a lack of physical activity is primarily due to the low level of energy expenditure compared to a higher level of energy intake. Interestingly, this resultant increase in adiposity is highly correlated with excess inflammation that leads to impairments in skeletal muscle function and size [46, 47]. Furthermore, while further research is needed to clarify potential mechanisms, a loss of skeletal muscle mass and function is also associated with a sedentary lifestyle [48]. Therefore, lack of activity further exacerbates the loss of muscle mass and function resulting from obesity-derived inflammation. Adding to this problem is that loss of muscle mass also accounts for a reduced level of physical activity [48]. It is clear that a sedentary lifestyle contributes to sarcopenic obesity [48, 49] and, unfortunately, leads to both disability and mobility issues greater than those with only one of these conditions [50]. The reader is referred to a comprehensive review on the topic [51].