HD patients N = 72 Normal controls N = 39  p Value
Human activity profile
 Maximum activity score 82.5 (13.5) 92 (5) <0.0001
 Adjusted activity score 72 (22) 89 (5) <0.0001
Time spent by monitor readings (%)
 Sleep or marked physical inactivity 81.9 ± 5.8 72.8 ± 6.0 <0.0001
 Light activity 14.4 ± 4.4 20.0 ± 4.5 <0.0001
 ≥ Moderate activity 3.7 ± 2.1 7.2 ± 3.0 <0.0001
Average daily physical activity (vector magnitude)
 Daily physical activity (mean of 7 days) 395,727 (222,350) 636,112 (243,634) <0.0001
 Day of HD 327,250 (188,085)
 1-day-post-HD 442,720 (246,824)a
 2-days-post HD 393,353 (275,123)b
6-min walk distance (meters) 441.3 ± 121.9 617.6 ± 63.2 <0.0001
Sit-to-stand test (no. cycles in 30 s) 15.9 ± 5.3 26.2 ± 5.4 <0.0001
Stair-climbing test (seconds per 22 stairs) 15.8 ± 11.0 9.8 ± 1.1 <0.0001