PMC:4157149 / 2308-2904 JSONTXT

{"project":"2_test","denotations":[{"id":"25152454-10613335-2052628","span":{"begin":496,"end":497},"obj":"10613335"}],"text":"To date, relatively few gene-environment interactions have been reported, in contrast with the large number of marginal associations discovered through genome-wide association studies (GWASs). One reason is that there might be relatively few subjects for whom the joint effect of gene and environment is high, so that very large samples are required to detect interactions. Another is that measurement error in either gene or environment can lead to substantial increases in required sample size.5 Thus, robust identification of a gene-environment interaction is regarded as a noteworthy finding."}