Acknowledgments The Centre for Dermatology and Genetic Medicine is supported by a Wellcome Trust Strategic Award (reference 098439/Z/12/Z). This work was supported by the Biotechnology and Biological Sciences Research Council, the Royal Society, and the UK National Institute for Health Research comprehensive Biomedical Research Centre award to Guy’s and St. Thomas’ NHS Foundation Trust in partnership with the King’s College London and King’s College Hospital NHS Foundation Trust. This study was also supported, in part, by DebRA UK, the Great Britain Sasakawa Foundation (award 4314), and the Strategic Young Researcher Overseas Visits Program for Accelerating Brain Circulation (S2404) from the Japan Society for the Promotion of Science. We also thank Venu Pullabhatla for assistance with transcriptomic data analysis and access.