(B) Representative sequence traces (top) for the two CCDC151 homozygous nonsense mutations detected in affected individuals. The examples are amplified from individual OP-675 (c.925G>T) predicting a premature termination of translation p.Glu309∗ and individual 71154 II:2 (c.1256C>A) predicting a premature termination of translation p.Ser419∗. The normal (WT) sequence is shown below.