Multisubunit axonemal dynein arm complexes contain heavy, intermediate, and light chain dyneins, and dyneins form a diverse protein family with roles in many different types of cellular movement, such as vesicle transport, nuclear migration, chromosome movements, spindle formation and orientation, and beating of cilia and flagella.67 The correct attachment of specific dyneins to different cell structures plays a major role in the maintenance of many essential cell functions.68 Therefore, dissecting out the mechanisms by which dyneins are targeted to and bind to cell organelles are of substantial interest. Current evidence suggests that CCDC151 is an atypical PCD-associated protein, probably not an integral component of the ODA-docking complex but required for correct axonemal docking and targeting of ODAs and essential for the assembly of both the ODAs and the ODA-DC apparatus.