PMC:4157146 / 41912-42752 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/4157146","sourcedb":"PMC","sourceid":"4157146","source_url":"https://www.ncbi.nlm.nih.gov/pmc/4157146","text":"In CCDC151 mutant human cilia, we found that the ODA component DNAH5 is not detectable in the ciliary axonemes, indicating that CCDC151 deficiency leads to defects of both known ODA types present in the proximal and distal ciliary axonemes.59 This is confirmed by the absence of ODAs in ultrastructurally analyzed cross-sections from CCDC151 mutant cilia, corresponding to the ciliary immotility observed by high-speed video microscopy. In agreement with these data, CCDC151-deficient Chlamydomonas, fly, zebrafish (flanders and morphants), planarians, and Ccdc151Snbl mice all have defective ciliary motility associated with a lack of axonemal ODAs.53,54 In contrast, we found that the axonemal IDA component DNALI1 was normal in CCDC151 mutant cilia, suggesting that CCDC151 deficiency does not result in defects of IDA axonemal assembly.","tracks":[{"project":"2_test","denotations":[{"id":"25192045-15750039-2045903","span":{"begin":240,"end":242},"obj":"15750039"},{"id":"25192045-24088566-2045904","span":{"begin":653,"end":655},"obj":"24088566"},{"id":"25192045-24067530-2045904","span":{"begin":653,"end":655},"obj":"24067530"}],"attributes":[{"subj":"25192045-15750039-2045903","pred":"source","obj":"2_test"},{"subj":"25192045-24088566-2045904","pred":"source","obj":"2_test"},{"subj":"25192045-24067530-2045904","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#93a5ec","default":true}]}]}}