(A) Enrichment of rare and potentially regulatory variants near the TSS of large-effect (β) cis-eQTL genes. Variants are restricted to those with a MAF < 0.01, within ENCODE TF binding and DNase I hypersensitivity peaks, and with a PhyloP score > 1. We observed increased enrichment of rare regulatory variants near the TSS of larger-effect-size genes in the family.